Structural and kinetic analysis of Schistosoma mansoni Adenylosuccinate Lyase ( Sm ADSL)
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چکیده
منابع مشابه
The kinetics of adenylosuccinate lyase.
Initial rate kinetics, product inhibition patterns, and equilibrium kinetics all indicate that cleavage of adenylosuccinate (AMP-S) by yeast adenylosuccinate lyase proceeds primarily by a reaction in which fumarate leaves the enzyme before AMP and cannot bind to free enzyme at kinetically significant concentrations. The alternate path, in which AMP leaves first, could be detected at equilibrium...
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Adenylosuccinate lyase (ASL) catalyzes two distinct but chemically similar reactions in purine biosynthesis. The first, exclusive to the de novo pathway involves the cleavage of 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) to 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) and fumarate and the second common to both de novo and the salvage pathways involves the cleava...
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ژورنال
عنوان ژورنال: Molecular and Biochemical Parasitology
سال: 2017
ISSN: 0166-6851
DOI: 10.1016/j.molbiopara.2017.03.006